Briefly, modeling RNA structures relies on two complementary approaches. The approach by homology is used when the structure of a sequence homologous to the sequence of interest has already been resolved experimentally. The main problem is to calculate an alignment between the known structure and the sequence. The ab initio approach is required when no homologous structure is known for the sequence of interest. It is also used, complementarily to the approach by homology, to predict the structure of parts of the sequence that does not correspond with the known structure. The present research project mainly focuses on comparative modeling and its combination with ab initio modeling.
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alain.denise
Créé
Mardi 18 mars 2014 19:21:02 CET
dernière modif.
Mardi 25 mars 2014 13:13:13 CET
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Ecole Doctorale Informatique Paris-Sud
Directrice
Nicole Bidoit Assistante
Stéphanie Druetta Conseiller aux thèses
Dominique Gouyou-Beauchamps
ED 427 - Université Paris-Sud
UFR Sciences Orsay
Bat 650 - aile nord - 417
Tel : 01 69 15 63 19
Fax : 01 69 15 63 87
courriel: ed-info à lri.fr